Manuscripts should be typed with double spacing on standard size paper. Spelling should conform to Webster’s International Dictionary and System International (SI) units should be used throughout. Abbreviations should be kept to a minimum and be defined at first mention. The title page should include:
- a concise and descriptive title for the paper
- the full name(s) of the author(s)
- the institutional affiliation of each author
- the name and address of the corresponding author (including e-mail address, telephone and fax numbers)
- an abbreviated title
- and any acknowledgment of financial or material support
Emphasis of headings should follow these font styles: Introduction, font 14 bold; subheading, font 12 bold, and sub-heading, font 12 italics.
ABSTRACT: An Abstract of four to six lines should precede the text. In brief form, this should describe the results and/or experimental methodology reported in the paper.
Nomenclature: Chemical names should be used for all drugs unless they are too cumbersome. Non-proprietary, generic names or names approved by the World Health Organization or the U.S. Adopted Names Council may be used; proprietary names must be avoided. The nomenclature of chemical compounds should conform with that adopted by the International Union of Pure and Applied Chemistry (IUPAC) and the International Union of Biochemistry. (See Biochemistry 1966, 5, 1455; Europ J Biochem., 1977, 74, 1). Systematic names may be found in Chemical Abstracts Index Guide, Appendix IV; Ring System Handbook, American Chemical Society, Columbus, Ohio, 1988. IUPAC rules have been published in Nomenclature of Organic Chemistry, Section A-F, H, Pergamon Press, Elmsford, NY, 1979. For steroid names, see Pure Appl. Chem., 61 (no.10), 1783-1822 (1989). For naming enzymes, see Enzyme Nomenclature, Academic Press, New York 1984. For carbohydrates, see Biochemistry, 10, 3983 (1971); for prostaglandins, see J. Med. Chem., 17, 911 (1974).
Abbreviations: Standard abbreviations should be used as given in the ACS Style Guide. In the interest of space economy, compounds should be given in a boldface (or underlined) number when first mentioned, and referred to by this number throughout the ensuing text. Common abbreviations may be used in formula schemes and Experimental Parts such as Me, Et, i-Pr, t-Bu, Ph, DMF, DMSO, IR, UV, NMR, GC, HPLC, TLC, bp, mp, dec., mL, g, mg, mol, mmol, h, sec, Et2O, EtOAc, MeOH.
Chemical Data and Analyses: All new compounds reported in the Journal should be homogeneous and characterized by modern, analytical methods, such as chromatographic and spectral data. Routine elemental analyses that agree with calculated values within 0.4% should only be reported as in the following example:
Anal. (C20H25No4), C, H, N. For natural, degradation, and metabolic products, the full elemental analysis must be recorded. On separate sheets, full analyses and physical data of all new compounds should be sent to the Editor. They will not appear in the Journal, but will remain deposited in the editorial files.
Biological Data: Quantitative (not merely qualitative) biological data must be reported for all compounds being tested. Biochemical and biological test methods must be referenced or described in sufficient detail to enable others to repeat the test. It is preferred that doses and concentrations be given in molar quantities. Salts of compounds should be designated.
References: should be listed alphabetically in the reference list. The format of listed references is: Last Name, Initial (year) Title. Jrnl Name (Abbreviated) Volume No:ppp--ppp (no period).
Example: Alfassi ZB, Mosseri S, Neta P (1989) Reactivities of chlorine atoms and peroxyl radicals formed in the radiolysis of dichloromethane. J Phys Chem 93:1380-1385
In text citations appear in parentheses as (Author last name, year); (Author and Coauthor, year); (Author et al., year).
Example: (Chang 1998); (Naik and Mohan, 2005); (Kime et al., 1987).
Synthetic Detail: Where new compounds are reported, some synthetic detail must be provided. There are two acceptable approaches. A standard, synthetic write-up can be included in the EXPERIMENTAL section. Alternatively, as is typical for a rapid communication, the synthesis can be explained in the CHEMISTRY section in narrative form. If the latter format is used, sufficient information necessary to characterize the new compound (e.g., melting point, recrystallization solvent, optical rotation) must be provided.